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Research Studies
A Prospective, Randomized Comparative Study of the Potential Anti-inflammatory and Anti-thrombotic Effects of Glargine Compared to NPH insulin
Paresh Dandona, Ajay Chaudhuri, Sandeep Dhindsa
Purpose: The purpose of this study is to find out if the addition of Glargine insulin to maximum dose of Sulfonylurea (Glyburide, Glipizide, Glucotrol XL, and Amaryl) and Metformin (Glucophage) in subjects with type 2 diabetes leads to greater reduction in several inflammatory (response of the body caused by injury or damage) and oxidative (damage to the body by production of charged particles) markers (an indicator) in the body as compared to the addition of NPH insulin. Sulfonylurea, Metformin, Glargine and NPH insulin are drugs approved by the FDA (Food and Drug Administration) to treat type 2 diabetes.
Eligibility: You are being asked to participate because you have poorly controlled type 2 diabetes mellitus and you are currently on two medications: sulphonylureas and metformin at the maximally effective dose.
Effect of Janucia (Sitagliptin) on Oxidative Stress in Obese Type 2 Diabetic Subjects
Paresh Dandona, Ajay Chaudhuri, Sandeep Dhindsa
Purpose: The purpose of this study is to determine if the addition of sitagliptin to diabetic patients will provide added benefit. We believe that sitagliptin provides these added benefits by suppressing free radicals (charged substances that cause damage to the body) and inflammation. Sitagliptin is a new oral hypoglycemic anti-diabetic drug of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. Sitagliptin has been shown to have fewer side effects in the control of blood glucose values. Obesity and diabetes are states of increased inflammation and can influence the free radicals and inflammatory markers (chemicals in the blood which increase due to inflammation in the body) and are also major risk factors for atherosclerotic disease. In this study we want to see the effect of sitagliptin on these markers. We believe that Sitagliptin may exert an anti-inflammatory effect in the human.
Eligibility: You are being asked to participate in this study because you have been diagnosed with type 2 diabetes mellitus, are obese and are on oral medication for your diabetes. The study doctors will go over other criteria that you will have to satisfy in order to be eligible for the study, during the screening visit.
The Effect of Byetta (Exenatide) on Insulin Requirement, Weight and Inflammation in Obese Type 2 Diabetic Subjects on Insulin
Paresh Dandona, Ajay Chaudhuri, Sandeep Dhinds, Husam Ghanim
Purpose: Exenatide has been shown to result in better glycemic control in type II diabetes patients. In our experience it has been found to be safe in type 2 diabetic patients on insulin and to reduce the requirements of insulin particularly the short acting insulin. Obesity and diabetes are states of increased inflammation; exenatide is expected to lead to decreased inflammation by virtue of better glycemic control and weight loss. The purpose of this study is to determine if the addition of Exenatide to diabetic patients will reduce the requirements of insulin particularly the short acting insulin. We also believe that exenatide will lead to decreased inflammation by virtue of better glycemic control and weight loss.
Eligibility: You are being asked to participate in this study because you have been diagnosed with type 2 diabetes mellitus, are obese and are on insulin therapy for your diabetes. The study doctors will go over other criteria that you will have to satisfy in order to be eligible for the study, during the screening visit.
Effect of Androgel on Atherogenesis, Inflammation, Cardiovascular Risk Factors And Adiposity in Type 2 Diabetic Males with Hypogonadotrophic Hypogonadism.: a Prospective, Randomized and Controlled-Study
Paresh Dandona, Ajay Chaudhuri, Sandeep Dhindsa
Purpose: The purpose of this study is to examine the effects of testosterone deficiency in men with diabetes. This will be done by comparing the changes in several body response indicators following treatment with testosterone in diabetic men with low testosterone levels and comparing them to diabetic men with low testosterone who are not treated with testosterone. These groups will also be compared with diabetic men who have normal testosterone levels.
Eligibility: You are being asked to participate because you are a male, with type 2 diabetes, between the ages of 30–60 years and have low or normal testosterone levels.
Vascular Benefits of Adding Carvedilol CR to Type 2 Diabetic Patients on ACEi: Effects on Oxidative Stress and Inflammation
Paresh Dandona, Ajay Chaudhuri, Sandeep Dhindsa, Husam Ghanim
Purpose: The purpose of this study is to determine if the addition of carvedilol to diabetic patients with high blood pressure who are already receiving the blood pressure medication, lisinopril, will provide added benefit to blood vessels when compared to treatment with lisinopril alone. We believe that carvedilol provides these added benefits by suppressing free radicals (charged substances that cause damage to the body) and inflammation.
Eligibility: You are being asked to participate in this study because you have been diagnosed with type 2 diabetes mellitus for at least four months, have high blood pressure and have been on treatment with the cholesterol-lowering drugs called statins for at least four months. The study doctors will go over other criteria that you will have to satisfy in order to be eligible for the study, during the screening visit.
Inflammation in Obesity: Modulation by Weight Loss
Paresh Dandona, Ajay Chaudhuri, Sandeep Dhindsa, Husam Ghanim, Elizabeth Szudzik
Purpose: The purpose of this research is to evaluate the status of inflammation in obese people compared to that of lean people and to see if the inflammatory changes in the obese can be reversed by weight loss. Inflammation has an effect on hardening of the arteries also called atherosclerosis. This research will evaluate whether the changes in inflammation bring about changes in arteries to protect them from atherosclerosis.
Eligibility: You are being asked to participate in this study either because you are a normal weight individual or an obese person without any medical problems. Your participation in this study is voluntary and you may discontinue your participation at any time without prejudice and without affecting future health care.
Division of Endocrinology, Diabetes, and Metabolism,
State University of New York at Buffalo and Kaleida Health
3 Gates Circle Buffalo, New York 14209, USA.