Division of Endocrinology, Diabetes, and Metabolism,
State University of New York at Buffalo and Kaleida Health,
         3 Gates Circle Buffalo, New York 14209, USA.

Diabetes and Endocrinology Center of Western New York

Effect of AndroGel on Inflammatory Mediators and Oxidative Stress in Type 2 Diabetics with Hypogonadism
Investigator: Paresh Dandona, MD
Sub-Investigators: Ajay Chaudhuri, MD  &   Sandeep Dhindsa, MD


Purpose:   This study was created to examine testosterone deficiency in men with diabetes.   This will be done by comparing the changes in several body response Indicators following treatment with testosterone in diabetic men with low testosterone levels and comparing them to diabetic men with low testosterone who are not treated with testosterone.

Eligibility for screening:  Male, Type 2 diabetic, Age 35-75 years

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By BMITool.com
Text Box: Effect of Januvia (Sitagliptin) on Oxidative Stress in Obese Type 2 Diabetic Subjects Investigator: Paresh Dandona, MD Sub-Investigators: Ajay Chaudhuri, MD & Sandeep Dhindsa, MD Purpose: The study was created to determine if the addition of sitagliptin to diabetic patients will provide added benefit.  We believe that sitagliptin provides these added benefits by suppressing free radicals(charged substances that cause damage to the body) and inflammation. Eligibility for screening: Male or Female, Type 2 diabetic, age 20-75 years, BMI > 30 kg/m2. Blood Pressure must be under control and HbA1c > 7%. Text Box: Study of Insulin for Anti-Inflammatory Action Investigator: Paresh Dandona, MD Sub-Investigators: Ajay Chaudhuri, MD & Sandeep Dhindsa, MD                                                                      Purpose: The purpose of the srudy is to see if insulin, which controls blood sugar in the body, will have an effect on inflammation.  This effect will be monitored keeping blood sugar level at a normal level.  We know that insulin reduces inflammation be suppressing inflammatory mediators, which can be measured in the blood, and white cells called mononuclear cells.  The purpose of our study is to measure these substances in the blood and white cells before, during and after insulin infusion.   Eligibility for screening: Male or Female, Healthy Normal Weight, type 1 diabetics with no complications, or type 2 diabetics with BMI > 30 kg/m2. Text Box: The Effect of Dairy Cream on Intracellular Lipid and Inflammation in Lean, Type 1 Diabetic, Type 2 Diabetic and Obese Subjects Investigator: Paresh Dandona, MD Sub-Investigators: Ajay Chaudhuri, MD & Sandeep Dhindsa, MD Purpose: This study was created to determine whether the saturated fat in the diet has any significant effect on fat accumulated inside your white blood cells, on free radical generation (charged molecules in the blood which are produced by the cells as a result of stimulant like infection, and other harmful chemicals or substances) and inflammatory markers (chemicals in the blood which increase due to inflammation in the body) in the blood and white cells in the blood in obese, diabetics and normal healthy individuals Eligibility for screening: Male or Female, Age 18 - 60 years, BMI <25 kg/m2 or >30 kg/m2 or have Type 1 or Type 2 Diabetes. Text Box: Vascular Benefits of Adding Carvedilol CR to Type 2 Diabetic Patients on ACE1: Effects on Oxidative Stress and Inflammation Investigator: Paresh Dandona, MD Sub-Investigators: Ajay Chaudhuri, MD & Sandeep Dhindsa, MD &  Hussam Chanim, PhD Purpose: This study was created to determine if the addition of carvedilol to diabetic patients with high blood pressure who are already receiving the blood pressure medication, lisinopril, will privide added benefit to blood vessels when compared to treatment with lisinopril alone. We believe that carvedilol provides these added benefits by suppressing free radicals (charged substances that cuase damage to the body) and inflammation. Eligibility for screening: Male or Female, Type 2 Diabetic for at least 4 mounts, Must have high blood pressure and have been on treatment with the cholesterol-lowering drugs called statins for at least four months.  Contact us for a more detailed assessment. Text Box: Modulation by Weight Loss Investigator: Paresh Dandona, MD Sub-Investigators: Ajay Chaudhuri, MD & Sandeep Dhindsa, MD & Hussam Chanim, PhD Purpose: The purpose of this research is to evaluate the status of inflammation in obese peopple compared to that of lean people and to see if the inflammatory changes in the obese can be reversed by weight loss.  Inflamation has an effect on hardening of the arteries also called atherosclerosis.  This research will evaluate whether the changes in inflammation bring about changes in arteries to protect them from atheroclerosis.  Eligibility for screening: Male or Female, BMI between 18.5 - 24.9 kg/m2 or 30 - 39.9 kg/m2

Division of Endocrinology, Diabetes, and Metabolism,
State University of New York at Buffalo and Kaleida Health,
         3 Gates Circle Buffalo, New York 14209, USA.

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